Simon Stone
BBC Sport at Old Trafford

Wayne Hennessey returns to a Premier League starting-line up for the first time since June 2020 and a 4-0 drubbing for Crystal Palace at Liverpool.

That was the Wales keeper's only post-lockdown league appearance and one of only three since March 2019.

Now he has to face Cristiano Ronaldo and Edinson Cavani.

Is it, of course, the time of year when lots of team changes happen but six does feel like a reaction from Ralf Rangnick to that display at Newcastle.

Interesting to see both full-backs being swapped out. This is the first time the German will get a proper match-day look at Luke Shaw and Aaron Wan-Bissaka.

Sounds like Burnley have a few Covid cases in their camp. Nick Pope is a big miss.

Ralf Rangnick makes six changes following Manchester United's 1-1 draw with Newcastle on Monday, with three of those at the back.

Aaron Wan-Bissaka, Luke Shaw and Eric Bailly all come into the defence, with Diogo Dalot, Alex Telles and Raphael Varane dropping out.

Meanwhile, Nemanja Matic replaces Fred in midfield and forwards Jadon Sancho and Edinson Cavani come in for Marcus Rashford and Bruno Fernandes, who is suspended.

Man Utd XI: De Gea, Wan Bissaka, Maguire, Bailly, Shaw, McTominay, Matic, Sancho, Greenwood, Cavani, Ronaldo.

Image source, BBC Sport

Burnley have not played since 12 December and make two changes to the side that drew with West Ham, with Wayne Hennessey replacing Nick Pope in goal and Aaron Lennon coming in for Jay Rodriguez.

The Clarets have only named seven substitutes from a possible nine on the bench.

Burnley XI: Hennessey, Lowton, Tarkowski, Mee, Taylor, Gudmundsson, Cork, Westwood, McNeil, Lennon, Wood.

Image source, BBC Sport

BBC Radio 5 Live

As well as this live text commentary, we have some radio coverage for you to take in if you so desire.

From 19:00 GMT through until 22:30 on BBC Radio 5 Live it is all football, with host Steve Crossman getting it all under way.

At 20:00, there is European football discussion, along with updates from Old Trafford of all the important stuff.

At 22:00, there's reaction to tonight's action with guests including Kevin Campbell and Luke Edwards.

And this is the situation at the bottom for Burnley...

Image source, BBC Sport

This is how it currently looks for Manchester United in that battle for a top-four spot...

Image source, BBC Sport

In the red corner we have Manchester United. The slightly fallen giants (it's easy to forget they finished second last season), who have had a change of direction of late and are now battling hard to gain access to the top table of elite European club football for another go at the big prize.

In the claret corner; Burnley. A Jack (of beanstalk fame) of the Premier League, who have surpassed resources and expectation in each of the last five seasons and are once again in a race to best relegation from the top-flight.

Whatever happen tonight, one of these teams will walk away disappointed and in further bother than they were before it.

Image source, Getty Images

Well, with around half the games gone the Premier League title race is pretty much done and dusted. Right?

Don't you worry, though, for the "best league in the world" still has some competitive fun left in it. Honest.

Tonight is a fine showcase of just that.