Wales suffer a record home defeat against South Africa, failing to score a point in Cardiff for the first time in 58 years.
Springboks end year top of world rankings with 11-try win that was marred by a straight red card for gauging on Alex Mann late on.
Gerhard Steenekamp and Ethan Hooker scored early tries, as South Africa started strongly.
Jasper Wiese added a third Springboks try before Morne van den Berg scored a fourth to finish the first half.
Wilco Louw, Sacha Feinberg-Mngomezulu and Canan Moodie continued South Africa's dominance early in the second half.
Andre Esterhuizen, Feinberg-Mngomezulu's second and Ruan Nortje's tries took the Springboks past the 50-point mark.
Etzebeth gets involved in the try-scoring action, scoring an 11th for the Springboks who reach 73 points.
Wales 0-49 South Africa
Wales make the changes with Reuben Morgan-Williams and Callum Sheedy at half-backs and Danny Southworth making his Test debut.
Chris Coleman came on moments earlier and good news with a return for Aaron Wainwright from the blood bin.
Moodie try, Feinberg-Mngomezulu con
No he didn't. He actually dropped the ball onto his foot so it's classed as a kick.
Morgan Morse almost got to the final bounce but it was kind for the South African wing who gets his second try.
It's getting ugly on the scoreboard very quickly.
Image source, Getty ImagesWales 0-42 South Africa
Again South Africa turn defence into attack in a split second.
Just as Wales were launching a rare attack, Dan Edwards's lose pass is gathered by Canan Moodie who hoofs the ball up field twice to score.
But did he knock on?
Wales 0-42 South Africa
Scott Williams
Wales centre on BBC Radio Cymru
We talk about discipline and Wales have not turned up to this game.
Handing the South Africans try after try.
Feinberg-Mngomezulu try & con
Wow... what a solo score.
Sacha Feinberg-Mngomezulu takes a quick tap penalty, shrugs off Gareth Thomas and then just steps on the gas to dive between the posts.
Strength and speed - that's what he is all about.
Image source, Getty ImagesWales 0-35 South Africa
James Hook
Former Wales fly-half on BBC Radio Wales
It’s a double blow with Wainwright going off and Plumtree Yellow. No one wants to see that happen.
A very unlucky injury to Wainwright, but that’s part of the game. Hopefully not as bad as it looks.
Wales 0-35 South Africa
To make matters worse for Wales, flanker Taine Plumtree has been shown the game's first yellow card for an infringement in the build up to that fifth Boks try.
It's getting worse for Wales very quickly.
Louw try, Feinberg-Mngomezulu con
The prop is over from close range after Esterhuizen's strong burst.
The centre is causing all sorts of trouble for Wales.
Wales 0-28 South Africa
Wainwright is off with blood pouring down from his right eye.
Watching the replay it appears he was actually caught by the fist of teammate Taine Plumtree. That's unfortunate.
Morgan Morse on for his second cap.
Wales 0-28 South Africa
Aaron Wainwright has stayed down on the pitch after trying to stop Andre Esterhuizen. He's only just returned from injury and Wales will not want to lose him.
Wales 0-28 South Africa
We've had some stirring Welsh opera at half-time... can that stir up a Welsh response on the pitch?
HT: Wales 0-28 South Africa
James Hook
Former Wales fly-half on BBC Radio Wales
Some key players have not dealt with the power of the South Africans at all. Dan Edwards, Ellis Mee have crumbled.
I really struggle to see what Steve Tandy’s team talk will be at half-time to turn things around.
HT: Wales 0-28 South Africa
Image source, Huw Evans Picture AgencyWell he's had a bright first half so far but there was a time when Sacha Feinberg-Mngomezulu was lining up for a Welsh college team.
As part of an exchange programme with his school in Cape Town, the Springboks fly-half spent a year at Llandovery College in Carmarthenshire.
Wales and Scarlets prop Harri O'Connor was part of that same college team in 2018-19.
"You don't normally get an exchange student player who is such a high calibre athlete," he recalled.
"Sacha rushed himself back from a broken bone and when he did play you could tell straight away he was a class above everyone else."
You can read more about how the school nestled in the west Wales countryside helped shape a growing superstar of the game.
Sacha Feinberg-Mngomezulu scoring for Llandovery College against Pembrokeshire College in 2018
HT: Wales 0-28 South Africa
Ian Gough
Former Wales international on BBC Radio Wales
Their aerial game was what started this game, and we expected the scrum to be dominant, and they did just that.
They spent so much time in Wales' half, and I think Rassie will be disappointed in not come away at half-time with more points on the board.
HT: Wales 0-28 South Africa
Image source, Huw Evans Picture AgencyThere are five Cardiff players in the Wales 23 and they will be pleased to hear how their team-mates got on without them before kick-off.
The Blue and Blacks continued their impressive start to the URC with a 29-14 win against Zebre in Parma.
Hooker Daf Hughes scored a hat-trick from driving line-outs in the first half and then flanker Taine Basham went over at the death to earn a bonus point.
Cardiff are top of the table, although they will be knocked down by either Munster or Stormers this evening.
Read the Cardiff report here.
HT: Wales 0-28 South Africa
Scott Williams
Wales centre on BBC Radio Cymru
Fair play to South Africa, everything has been perfect.
They make everything look really easy and Wales are struggling.
That's the end of the first half which has been frankly one-way traffic.
Wales have barely touched the ball and when they have, they have either kicked it away or missed the lineout.
South Africa in total control after four tries.
Image source, Huw Evans Picture AgencyWales 0-28 South Africa
James Hook
Former Wales fly-half on BBC Radio Wales
You can’t give someone that much of a run up.
Wales need to close that space down, today they haven’t and been punished.
Van der Berg try, Feinberg-Mngomezule con
No they can't, especially when Andre Esterhuizen is in the opposition team.
The 183kg centre smashes into the Welsh midfield, crashing through Joe Hawkins and Dan Edwards and it needs a third tackler to bring him down.
But scrum-half Morne van der Berg is on his heels to pick up and dive over for his fifth test try in only six appearances.
Image source, Getty ImagesWales 0-21 South Africa
How quick can South Africa turn defence into attack.
Canan Moodie breaks a tackle to start another counter-attack that is finally halted - illegally - close to the Welsh posts.
Can Wales hold them out before half-time?
