Andy Murray's first service game took more than five minutes but he's breezed through the next two and only dropped one point in those games.

A hold to love takes him to a 3-2 lead.

This is looking like this is going to be a good test of the Murray fitness as Nishioka sends the 2012 champion scampering around the court. But all the effort for Murray comes to nothing as Nishioka holds after saving two break points. 2-2.

Kyle Edmund is another one watching here, cheering on his fellow Brit.

An epic 19-shot rally, played out from the respective baselines, before Nishioka saves himself for the second time with a brilliant cross-court winner with Murray nowhere. Back to deuce.

The first break point of the match is for Murray, but he puts too much juice on it and out it goes. But here comes his second chance for a break...

As always we want your say on all the action so tweet us using the hashtag #bbctennis to get involved.

Early questions for you: How far will each of the British players go this fortnight? Who is going to win the men's and women's titles and why?

No problems for Andy Murray in that game, holding it to 15 as a Nishioka passing attempt was unsuccessful to give the Brit a 2-1 lead, still on serve.

Naomi Broady
British player on BBC Radio 5 Live Sports Extra

I think you'll see a lot of players watching Andy today. I think everyone's curious.

We all love to watch the sport. The only strange thing is that they're probably going to be your opponents later in the tournament so you're constantly being spied on.

One of the quirks of this tournament is the fact that for safety reasons the top players have suites facing out on to Arthur Ashe so the stars can just go on the balcony and watch some tennis right in front of them.

Alexander Zverev, the world number seven, is among those spotted, eating his lunch.

A hold to 15 from Nishioka gets his first game on the board. Murray's first service game took longer than five minutes, but Nishioka comes through relatively comfortably in his.

Murray will be hoping there aren't too many 21-shot rallies, especially when it doesn't go his way. But that's what has just happened as Nishioka, glued to the baseline and utilising an impressive backhand again and again takes the point.

Naomi Broady
British player on BBC Radio 5 Live Sports Extra

You really want to win that first service game. Murray's rehab is still ongoing. At the Battle of the Brits he was constantly in the gym doing his exercises.

He does a lot of specific weights to strengthen a lot of muscles around his hip. He's putting a lot of hours in throughout the day.

In his first Grand Slam match in 20 months, after a couple of hip surgeries, Andy Murray takes the lead today as a Nishioka backhand drifts out.

A slice backhand up the line, followed by a nifty spin, shows Murray looks in good shape, Nishioka leaps but nets and that is game point for Murray.

He can't take it at the first opportunity as a fine forehand from the Japanese player is perfect and we're at deuce. A tough opening game.

Andy Murray is ready to go. He is serving first. He's back in Grand Slam action.

And many messages of support for Suarez Navarro have come in from her fellow players.

Sabine Lisiciki wrote: "Dear Carla, you’ve always been a fighter & you will fight through this. Wishing you all the strength needed to win this though battle. The Tennis world is with you."

Simona Halep wrote: "Carla. I’m so shocked and sad to read this news. I’m thinking of you and know that a strong and special person like you can get through this. Big kisses, Simo."

Petra Kvitova wrote: "Carlita.. If I know somebody who can deal with this, it’s you! You are a fighter and great champion with lots of positivity. Sending you strength and hugs."

Some sad news to bring you from the women's game and Spain's Carla Suarez Navarro, formerly ranked sixth in the world, has announced she has lymphoma - a form of cancer - and needs six months of chemotherapy.

In the last hour, the 31-year-old, who withdrew from the US Open two weeks ago, posted a video on Twitter.

She said: "A few days ago I was diagnosed with lymphoma. It's a Hodgkin lymphoma. I need to go through six months of chemotherapy.

"I'm fine and calm at the moment, willing to ace whatever comes. See you soon."

As he just hinted at, Japan's Yoshihito Nishioka has experience of playing on Arthur Ashe as this was his setting for his 2018 first-round match when he lost 6-2 6-2 6-4 to Roger Federer.

Nishioka, 24, is ranked 49th in the world and beat Britain's Dan Evans earlier this year in the second round of the Australian Open, before losing to Novak Djokovic a round later.

That was Nishioka's best Grand Slam performance of his career.

Yoshihito Nishioka said: "It's very exciting to play. I'm very happy to be back here. I'll try to do my best against one of the best players in the world.

"I want to show the many Japanese fans my best tennis and we'll see how I go."

Andy Murray said: "It's great, I'm pumped to get out here and play. It's different circumstances than usual but I'm still excited.

"For all the players having not played five sets for a while... conditions are nice today but it's tough for everyone."