France produced a second-half power show to shrug off a resilient Wales by 38-7.
Wales led through a penalty try as they aimed to end a run of nine defeats in a row at the hands of France.
But the visitors simply had too much muscle, class and know-how to be denied a comfortable 38-7 win at the Arms Park.
France even survived a spell down to 13 players as Madoussou Fall Raclot hit back before seizing control through Manae Feleu, Lea Marie and player of the match Pauline Bourdon Sansus.
Anais Grando added to her try last week with two late scores but it was not enough to prevent France slipping to second in the Six Nations table, behind England on points difference after the Red Roses crushed Scotland.
What else has happened today?published at 18:34 BST 18 April
18:34 BST 18 April
HT: Ireland 45-10 Italy
Image source, Getty Images
Dominant England spoiled Scotland's record-breaking afternoon at Murrayfield with a 12-try 84-7 win which keeps them on course for another Six Nations title.
A total of 30,498 fans were in the stands at Murrayfield - a record for a standalone women's sporting event in Scotland - and they were ultimately treated to a 35th consecutive Test win for the Red Roses after a powerful display.
Ellie Kildunne, starting on the wing for the first time in the Six Nations, was as lively as ever and scored twice in the first half, while captain Meg Jones, Kelsey Clifford and Emma Sing added further first-half scores.
But the Murrayfield crowd did have a moment to savour in the first half when Helson Nelson's chip over the top and Chloe Rollie's pass was finished well by Rhona Lloyd, who surged over for a try which was cheered to the rafters.
However, it was only a fleeting moment as England added seven second-half scores as Amy Cokayne, Sarah Bern, former captain Marlie Packer, Sadia Kabeya, Mia Venner, and Haineala Lutui all bolstered the scoreboard further as England laid down another marker in their pursuit of an eighth straight Six Nations title.
'Sensational' Irelandpublished at 18:26 BST 18 April
18:26 BST 18 April
HT: Ireland 45-10 Italy
Grace Davitt Former Ireland centre on BBC iPlayer
That was great work by Ireland to keep the ball alive, great moving of the ball. Ireland have been sensational and what a homecoming for Beibhinn Parsons.
Converted Try - Ireland 43-10 Italypublished at 40 mins
40 mins
Beibhinn Parsons (con O'Brien)
HAT-TRICK FOR BEIBHINN PARSONS! IT'S STUNNING RUGBY!
From their own half, Ireland move it through the hands with O'Connor and Parsons key.
Aoife Wafer does what she does best and makes more ground, and she pops it back inside for Parsons to race the length of the 22 for her third try of the day.
That really is superb, and O'Brien converts for good measure.