Brian Smith, London Irish coach:
"We didn't control the ball well enough and they out-muscled us in the tackle," said Smith.
"Fair play to Sale, they have a very threatening backline and they took their opportunities well."
London Irish have only won one of their three opening games of the Guinness Premiership season.
Sale: Larrechea, Cueto, Taylor, Seveali'i, Robinson, Hodgson, Courrent, Sheridan, Bruno, Turner, Jones, Schofield, White, Lund, Chabal.
Replacements: Ripol for Larrechea (51), Todd for Taylor (78),Wigglesworth for Courrent (78), Stewart for Turner (60), Day for Schofield (70), Lobbe for White (75), Titterrell for Lund (63).
London Irish: Armitage, Staniforth, Penney, Catt, Bishop, Everitt, Hodgson, Hatley, Flavin, Skuse, Strudwick, Roche, Magne, Dawson, Murphy.
Replacements: Geraghty for Catt (70), Willis for Hodgson (62), Collins for Hatley (66), Tait for Flavin (62), Hardwick for Skuse (40), Kennedy for Roche (70), Gustard for Magne (43).
Att: 7,246