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Cardiff Blues will host three-times champions Toulouse in the first of the Heineken Cup quarter-finals on Saturday, 11 April at 1530 GMT.
The victors will face the winners of Leicester against Bath, which kicks off at 1800 the same day, in a semi-final.
Defending champions Munster will host the Ospreys on Sunday, 12 April.
That clash, at 1300, will be followed by the final quarter-final between Harlequins and Leinster, at 1530, with the two winners meeting in the semis.
Either the Blues or Toulouse will have home-country advantage in the semi-finals, while either holders Munster or the Ospreys will also remain in their home country if they win their quarter-final.
Munster saw off Sale, Clermont Auvergne and Montauban to win Pool One and will be favourites against the star-studded Ospreys.
The Blues were the only side to remain undefeated in the pool stage, scoring 202 points in six matches and topping a group which also featured Biarritz, Gloucester and Calvisano.
However, their form in the Magners League has been poor and last year's runners-up Toulouse, currently riding high in the French Top 14, will be a different proposition.
Remarkably, Toulouse are the only French side in the last eight after Stade Francais' shock failure to advance from Pool Three.
The quarter-final in Cardiff, which could be switched from the Arms Park to the Millennium Stadium next door, is a repeat of the first ever Heineken Cup final in 1996, which Toulouse won 21-18 in extra-time.
Harlequins, who have reached the knock-out stages for the first time since 1998 after beating Stade Francais twice in the pool stage, will face Leinster, who topped Pool Two ahead of Wasps.
The other quarter-final will see English rivals Leicester and Bath, who both won their respective pools, clash in a repeat of their meeting in the last eight in 2006.
On that occasion Bath, despite being reduced to 13 men late on, held on to win 15-12 at the Walkers Stadium.
Heineken Cup quarter-final draw
Sat 11 April:
Cardiff Blues v Toulouse (1530 GMT)
Leicester v Bath (1800 GMT)
Sun 12 April:
Munster v Ospreys (1300 GMT)
Harlequins v Leinster (1530)
Heineken Cup semi-final draw
matches to be played 2-3 May
Cardiff Blues/Toulouse v Leicester/Bath
Munster/Ospreys v Harlequins/Leinster
European Challenge Cup quarter-final draw
matches to be played 10-12 April
London Irish v Bourgoin
Northampton v Connacht
Saracens v Newcastle
Worcester v Brive
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