Could Farscape have worked with a different cast?
It's hard for me to imagine that at this point, because to me the cast and the characters have merged, they've fused into one large indistinguishable grey mass and it's really difficult to imagine anybody else playing any of the roles.
Part of that is because when you start to write for a specific actor you start to see what they bring to the character. They've got their own ideas and their own little twists on what you write and you start to write to that. Sometimes the analogy I use is a composer who writes a concerto for a specific concert pianist, knowing that it will suit that person's particular skills. Then hearing it you say, "Oh they've really done much better than what I gave them." So it's hard to imagine with any other cast for me.
The thought is sort of mind boggling unless it was an alternative reality Farscape, which is certainly not beyond us to try that.