The semi-autobiographical story, set against the backdrop of the mid-'90s Detroit rap scene that spawned Eminem, co-stars Kim Basinger, Mekhi Phifer and Brittany Murphy.

The festival, which takes place in the Canadian city from 5 September, will feature a number of premières. including the North American première of Brian De Palma's film Femme Fatale.

The movie, in film noir style and starring Antonio Banderas and Rebecca Romijn-Stamos, is both written and directed by De Palma and will close the festival on 14 September.

Selma Hayek stars as the troubled artist in Frida

Frida, the Salma Hayek biography of Mexican artists Frida Kahlo, will also receive its North American première at the festival.

Hayek stars with Alfred Molina, Ashley Judd, Geoffrey Rush, Antonio Banderas and Edward Norton in the film, which explores Kahlo's relationship with her husband, Mexican artist Diego Rivera.

The Four Feathers, by Indian-born Shekhar Kapur, who directed Bandit Queen and Elizabeth, will receive its world première.

Adapted from the AEW Mason novel about a British officer in Africa in 1875, it stars Heath Ledger, Wes Bentley, Kate Hudson, Djimon Hounsou and Michael Sheen.

De Palma recently directed Nicholas Cage in Snake Eyes

The festival will also host a Discovery section, devoted to up-and-coming directors and including 16 feature films from 16 countries.

Discovery includes the world première of Try Seventeen, starring Elijah Wood as a 17-year-old who embarks on a journey of self-discovery when he goes off to college.

Toronto's Wavelengths programme focuses on avant-garde and experimental film, and features 25 films from five countries, including Janie Geiser's Ultima Thule and Lewis Klahr's Daylight Moon.

The 10-day festival is one of the major film events in the world, along with Cannes, Berlin and Venice.

Last year the festival's closing ceremony was shelved in the wake of the 11 September attacks on the US.