Jackson plays an FBI agent escorting a witness to Los Angeles
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Airborne thriller Snakes on a Plane has topped the North American box office in its first weekend on release.
But the film's modest takings of $15.3m (£8.1m) only took it marginally ahead of last week's champion, Will Ferrell's motor racing comedy Talladega Nights.
The Samuel L Jackson film was expected to perform better off the back of the wave of hype that preceded its release.
The $30m (£15.9m) action movie was released at the same time in the UK without being screened to critics.
The film's weekend tally includes $1.4m (£740,757) takings from preview screenings held on Thursday night, according to studio estimates.
If these are not taken into account, Talladega Nights: The Legend of Ricky Bobby is still the top film in the US and Canada.
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NORTH AMERICAN BOX OFFICE
1. Snakes on a Plane
2. Talladega Nights: The Ballad of Ricky Bobby
3. World Trade Center
4. Accepted
5. Step Up
6. Barnyard: The Original Party Animals
7. Little Miss Sunshine
8. Pirates of the Caribbean: Dead Man's Chest
9. Material Girls (above)
10. Pulse
Source: Exhibitor Relations
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Oliver Stone's 11 September drama World Trade Center held steady in third place with weekend takings of $10.8m (£5.7m).
The comedy Accepted, about a teenager who sets up his own fake college after he fails to secure a place at a real one, made its debut at number four, earning $10.1m (£5.3m).
The only other new entry in this week's Top 10 is Material Girls, a comedy starring pop star Hilary Duff and her older sister Haylie.
The film opened in ninth place with weekend takings of $4.6m (£2.4m).
The Pirates of the Caribbean sequel, Dead Man's Chest, dropped two places to eight but remains the most profitable film in this week's rundown.