Plans are already in place to refurbish Derriford Hospital
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Derriford Hospital in Plymouth is advertising across Europe for firms to design the city's new multi-million pound hospital.
The Vanguard project will see a new hospital complex built and the existing Derriford Hospital refurbished.
It will cost £300m, with the money coming from a private finance initiative (PFI).
Plymouth Hospitals Trust has just issued a notice inviting bids from potential designers.
'New choices'
Hospital managers say it is a significant step forward for the project.
Joint director of planning Andy Ibbs said: "There are still hurdles to overcome before we can be absolutely certain that Vanguard will be delivered, including financial ones.
" However, it is now much more likely."
He added: "We are aiming to deliver something that has the potential to make a real difference to local people by providing new choices, better services and faster treatment in an improved environment."